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doi: 10.1007/s00394-019-01931-8 149 MohrAEBasileAJMelisaSCSweazeaKLCarpenterKC

First, the cellular delivery of mtREs could raise safety concerns

Herbal GLP-1 patches might have these potential benefits, but their effectiveness is questionable 19

Because high glucose levels increase oxidative stress, maintaining adequate antioxidant defenses is an important part of metabolic optimization

Thus, more frequent dosing is associated with less fluctuation in steady state levels

thus, the adaptability and survival of MSCs within IVDs require further study ( Human clinical trials have predominantly focused on MSCs owing to the promising outcomes exhibited by MSCs in reducing pain and improving function in patients with IVD degeneration (Table 1)