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Mitochondria, the Key Aerobic Microbe for Eukaryotic Cell Evolution Mitochondria originated about 1.5 billion years ago from a prokaryotic origin linked to archaebacterium (archae meaning ancient bacteria)

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303 Under pro-ferroptotic stress, the intracellular DAMPs, including double-stranded DNA and mitochondrial DNA, can activate the cyclic GMP-AMP synthase (cGAS)/stimulator of interferon genes (STING) pathway, leading to the release of interferon (IFN)

Finally, combining vectors with biocompatible scaffolds or hydrogels may extend intra-articular retention and promote localized expression