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Vzquez-Boland et al., 2001b)

This establishes a chronic inflammation-oxidative stress vicious cycle

The estimates of DILI incidence fluctuate significantly, from 1 in 10,000 to 1 in 1,000,000 cases, influenced by variable factors such as diagnostic criteria, detection capabilities, population demographics, drug types, cultural factors, and reporting practices

If prevention fails, holistic and personalized management should be taken as soon as possible through timely detection and diagnosis, considering target organ protection, comorbidities, treatment goals, and other factors in reality

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