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Crucially, FOXO4-DRI selectively induced apoptosis in senescent TM3 Leydig cells by causing nuclear exclusion of active Ser15-phospho-p53, leading to a significant increase in apoptosis rate and altering pro-apoptotic (BAX, cleaved-Caspase3 increase) and anti-apoptotic (BCL-2 decrease) protein levels

This process helps rejuvenate aging or damaged skin while strengthening the skin barrier

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Shigeki Watanabe Reference: Imoto et al., 2022, Neuron

The method of any one of embodiments 79-151, wherein the composition further comprises an antimicrobial agent

The effect of AOD-9604 on the underlying mechanisms of osteoarthritis was demonstrated by changes in the gross clinical examination as well as changes in the microscopic structure of the cartilage in the affected joints