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Metformin use is also associated with modulation of energy balance resulting in weight loss

The conserved SKN-1/Nrf2 stress response pathway regulates synaptic function in Caenorhabditis elegans
10.1063/1.4993958 22 FengB.ZhuH.GuanJ.ZhaoL.GuJ.YinL.et al (2014)

Alterations of the morphological findings of the retina and optic nerve
thaliana DHAR genes are expressed in most organs tested

Vascular depression' hypothesis
