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Since few years, targeted therapies emerged as a promising senolytic approach, and several molecules are under clinical evaluation

Sagara JI, Miura K, Bannai S

A high intracellular ratio of reduced glutathione to oxidized glutathione (GSH/GSSG ratio) is protective of microtubules in their polymerized state by the preventing oxidation of cysteine residues in tubulin subunits

doi: 10.1186/s12967-023-04310-4 285 ZhaoJ.ZhuY.YangJ.LiL.WuH.de JagerP

Cancer Res (2012) 72(22):592133

A 20-week pilot trial examined the safety and tolerability of increasing dosages of coenzyme Q 10 (1,200 mg/day, 2,400 mg/day, and 3,600 mg/day) in eight healthy subjects and in 20 patients with Huntingtons disease