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doi: 10.1038/srep37002

The downsides are cost and convenience

It should be noted that GSH ester tends to be enriched inside cells due to its hydrophobic nature and esterase-catalyzed hydrolysis of GSH ester to GSH

Influence of Age on Drug Responses Variation in drug responses may be due to several factors such as: Diminished cardiac output: A reduction in cardiac output reduces hepatic perfusion which may decrease delivery of drug to the liver for metabolism
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