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Eur J Neurosci (2000) 12(10):37218.10.1046/j.1460-9568.2000.00229.x 12 CarneyMWRavindranARinslerMGWilliamsDG

22 Increased inflammation and oxidative stress were also responsible for TMAO-induced inhibition of angiogenesis and perfusion recover after hindlimb ischemia

Taking the knife to neurodegeneration: a review of surgical gene therapy delivery to the CNS

These Phase II reactions further increase the water solubility of the metabolites, aiding in their elimination from the body

Therefore, systematically summarizing and promoting further research on the biological functions of redox sensors is of significant importance for a better understanding of the mechanisms by which redox regulation contributes to the occurrence and progression of diseases

Acknowledgements The authors thank the members of the Gerhart-Hines laboratory for discussions