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Expert Rev Clin Pharmacol 6(3):323332 Uckert S et al (2001) Phosphodiesterase isoenzymes as pharmacological targets in the treatment of male erectile dysfunction

Carnitine is most concentrated in tissues that use fatty acids as their primary fuel, such as skeletal and cardiac muscle because its required for mitochondrial beta-oxidation of long-chain fatty acids for energy production.1 Carnitine Deficiency and Dietary Sources The human body needs about 15 mg of carnitine per day from a combination of endogenous and dietary sources, and a typical omnivore diet provides up to 10 times that amount.2 Healthy individuals generally synthesize enough carnitine to prevent deficiency

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The following individuals should avoid using L-carnitine: Epileptics: It may lower the seizure threshold

JLF drafted the review