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This work was also funded by the Guangdong Provincial Bureau of Traditional Chinese Medicine (No.20241285) and Guangdong Basic and Applied Basic Research Foundation (No.2022A1515110790 and 2024A1515012478)

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Anti-IL-5 biologic therapy has been developed to treat these patients, as IL-5 is the primary cytokine involved in eosinophil survival

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Later work confirmed LL-37 acts as a self-antigen that T-cells in many psoriasis patients directly attack, tying it deeper into the disease mechanism (Lande et al., Nat Commun, 2014)

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The mechanism pathways are plausible

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