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Iron overload promotes M1 macrophage polarization and increases the M1 macrophage markers levels (IL-6, IL-1, and TNF-), leading to synovial damage

In particular, BHB, in addition to its role as an energy source, also has a variety of molecular signaling and regulatory functions in a wide range of human diseases ( 4.1 Epigenetic regulation BHB has been reported as a Class I histone deacetylase (HDAC) inhibitor and an endogenous neuroprotective epigenetic modifier ( 4.2 Gut microbiome Gut microbes are also known to be involved in the development of many diseases

Mitochondrial complex I inhibition triggers a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis in melanoma cells

Simvastatin inhibits activation of nadph oxidase/p38 mapk pathway and enhances expression of antioxidant protein in parkinson disease models

Reduced NO bioavailability induces LSEC capillarization characterized by loss of the LSEC window pore and basement membrane formation and leads to an imbalance in its secretion of vasoactive substances, which contributes to MASLD progression