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These activated CAFs upregulate glycolytic enzymes, glucose transporters (GLUT1, GLUT3), and lactate dehydrogenase A (LDHA), leading to enhanced conversion of glucose to lactate and ketone bodies (128, 133)

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However, functional effects of many polymorphisms remain unclear, and their influence can be gene- and cell type-specific, highlighting the complexity of genetic contributions to neurocognition (143)

For example, in Arabidopsis, the overexpression of the gene encoding peroxisomal 4CL involved in the oxidation of p-coumaric acid for the subsequent biosynthesis of UQ (Figure 2) led to an approximately 1.5- to 2-fold increase in UQ accumulation [16,17]

Park K, Chang GC, Curigliano G, Lim WT, Soo RA, Molina-Vila MA, et al

USA 99 , 1139311398 (2002)