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As evidence for the possibility of an early life disturbance creating lasting effects on barrier function, the trauma of maternal separation during weaning has been shown to predispose adult rats to enhanced intestinal permeability in response to stress [51]

Under such conditions it is essential to provide the body with the key nutrients involved in GSH synthesis in order to sustain functionally appropriate levels of GSH

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PubMed: (peer-reviewed) Leyden J, et al