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Taking advantage of this information, several PROTACs resulting from the binding of ML162 derivatives and ligands to cereblon/VHL E3 ligases were synthesized to evaluate the impact of forced GPX4 degradation on cancer cells

Disclosure The authors declare no conflicts of interest

The carefully balanced ingredient profile ensures effective absorption, suitable for all skin types in a range of cosmetic and wellness routines

At four weeks post inoculation, fecal samples from 3 animals from the BacA group and 4 animals from each IcL and wild type group were MAP culture positive

Ethics declarations Conflict of interest The authors declare that there are no competing interests

(2023) 15:eabo1557