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In addition, investigation of the mitochondrial function of 1919 PSPH amp and PSPH V116I GBM cells revealed an elevated proton leak in 1919 GBM PSPH V116I cells (Fig

Biomacromolecules 26 , 579590 (2025)

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In microglia, the NLRP3 inflammasome is a multiprotein complex composed of a sensor (NLRP3), an adaptor (ASC), and an effector (caspase-1)

Also depletion of AMBRA1 promotes interaction of D-cyclins with CDK2, resulting in resistance to CDK4/6-inhibitors (20, 22)

Meanwhile, a drug retaining 4060% of its form despite hepatic metabolism is said to have undergone hepatic/renal excretion