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A limitation to the therapeutic potential of the senolytic pan-BCL inhibitors ABT-263/ABT-737 is their tendency to cause severe thrombocytopenia(Schoenwaelder et al., 2011)

2009, 296 (6): L888-900

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Copper Is Required for Oncogenic BRAF Signalling and Tumorigenesis

Suppression of erythropoiesis : This can occur due to inflammatory cytokines (as indicated above) or uremic toxins, both of which can inhibit erythropoiesis or inhibit the action of erythropoietin on erythroid progenitors (some authors refer to this as decreased erythropoietin activity)

[DOI] [PMC free article] [PubMed] [Google Scholar] 153.Falk DJ, et al