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Oncogenic KRAS regulates amino acid homeostasis and asparagine biosynthesis via ATF4 and alters sensitivity to L-asparaginase

AMP is a potent activator of PFK-1 in the presence of ATP

Conversely, downregulated genes were enriched for cellcell adhesion, indicating disrupted structural connectivity

Ashrafi, G., Wu, Z., Farrell, R
