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Although it is generally accepted that the OPC population remains stable in the aged brain, a more recent study found significantly reduced OPC (NG2 + ) density in the corpus callosum of 18-month-old mice (Rivera et al., 2021)

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In addition, the docking scoring function mainly evaluates static binding affinity, which makes it tough to accurately simulate the complex physiological environment in living organisms (such as solvation effects, entropy changes, etc.), which might result in false positives in experiments for molecules that are predicted to bind well (Gioia et al., 2017

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