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[2] It functions primarily as an antioxidant, with intracellular concentrations reaching up to 20 mM in cells

Hum Mol Genet 17:490505 Essaghir A, Dif N, Marbehant CY, Coffer PJ, Demoulin JB (2009) The transcription of FOXO genes is stimulated by FOXO3 and repressed by growth factors

Free Radic Bio Med 86:102117

In terms of functional mechanisms, kynurenine and its downstream metabolites affect immune cell fate through the aryl hydrocarbon receptor (AhR), including regulation of the Treg/Th17 balance

[Abstract] J Antimicrob Chemother

DCF fluorescence was acquired on the Attune NxT (ThermoFisher) flow cytometer and analyzed using FlowJo software (Tree Star, Ashland, Oregon)
