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The primary cause include low bone mineral density (BMD) (54), oxidative stress from an imbalance between reactive ROS and antioxidants (55), and an imbalance between osteoclasts and osteoblasts due to estrogen deficiency and inflammation, marked by increased pro-inflammatory cytokines like TNF and T-cell expression of RANKL (56, 57)

p53 represses the mevalonate pathway to mediate tumor suppression

Duan Sahbaz, E.S

Also, additional deletion of MCT8 in the D3KO mice ameliorates the phenotype indicating the relevance of MCT8 for intracellular T3 levels (208)

How Spinal Cancer May Cause Back Pain Tumors in the spinal column may cause back pain by: Expanding and/or weakening the bone Causing the vertebrae to easily fracture Compressing the spinal cord and/or spinal nerve roots Additional factors, such as spinal instability, may also be involved in spinal tumors causing back pain