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Following relevance-based screening, approximately 20 to 35 studies were included in the final narrative synthesis
Okorie OE, Ko SH, Go S, Lee S, Bae JY, Han K, et al
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In vivo studies reported that out of more than 20 known isoforms of claudins, the absence of claudin-5 and claudin-3 lead to loss of BBB integrity and barrier disruption, which, in turn, disturbs the proper functioning of BBB [1, 21, 22]
Madsen et al
However, N-acetylcysteine treatment significantly improves renal function and decreases the expression levels of TLR4, IB, IKK, and p65 proteins
