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mHTT impairs mitochondrial biogenesis, disrupts calcium handling, and promotes fission over fusion, leading to fragmented and inefficient mitochondria

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The transcription complex formed by ERR- and PGC-1 induces the expression of vascular endothelial growth factor (VEGF), a potent stimulator of angiogenesis [128,129]

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This approach highlights the critical importance of analyzing pre-existing experimental data to develop a biologically coherent model of pathogenesis, subsequently validated through laboratory experimentation