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found that ERK negatively controlled autophagy by activating mTOR, which contributed to neuronal survival after experimental ischemic stroke injuries

This is a particular issue for drug metabolizing enzymes, especially cytochrome P450, which are substantially downregulated [139]

Marcus FI, Zareba W, Calkins H, Towbin JA, Basso C, Bluemke DA, Estes NM III, Picard MH, Sanborn D, Thiene G, Wichter T (2009) Arrhythmogenic right ventricular cardiomyopathy/dysplasia clinical presentation and diagnostic evaluation: results from the North American Multidisciplinary Study