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transcriptomics map of key RMT receptors in mouse and human brain microvessels and peripheral tissues, important to translational studies of biodistribution, efficacy and safety of antibodies developed against these receptors

Higher doses or specialized formulations are often required for oral peptides to compensate for degradation and limited systemic uptake

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A randomized phase II clinical trial showed that this antibody in combination with epirubicin, cisplatin, and capecitabine (ECX) could prolong PFS in advanced gastric cancer patients relative to the control group, especially in patients with high c-Met expression ( Onartuzumab is a recombinant humanized anti-c-Met monoclonal antibody, which is produced in Escherichia coli (Shah et al., 2016)