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Bertrand F, Philippe C, Antoine PJ, Baud L, Groyer A, Capeau J, Cherqui G

Glutathione is one of the key tools the liver uses to bind, neutralize, and help remove harmful compounds from the body

GSH biosynthesis is an endergonic process (ATP hydrolysis is coupled), in which firstly glutamate and cysteine condense to yield -glutamylcysteine (reaction catalyzed by glutamate-cysteine ligase, E.C

doi: 10.1016/j.carbpol.2022.120470 143

J.LiuX.WuX.et al

Further analyses indicated that the activation of NRF2-mediated transcription that was associated with lapatinib-induced persistent and resistant phenotypes coincided with a subsequent increase in glutathione metabolism