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Kesimpta (ofatumumab) is an anti-CD20 antibody approved for the treatment of adults with relapsing forms of multiple sclerosis (MS), including clinically isolated syndrome, relapsing-remitting MS (RRMS), and active secondary progressive MS (SPMS)

These purified Cys-peptides are then analyzed on an Orbitrap instrument (Q-Exactive HF-X) operated in high-resolution MS1 DIA mode (HRMS1-DIA) to quantify Cys-containing peptides (Tahir et al., 2020)

Absence of data in these cases should be distinguished from absence of effect at lower doses

292 In summary, the use of metformin as a potential inhibitor of NETs formation and NETosis shows promise in the treatment of GA

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