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doi: 10.1016/j.jceh.2016.02.003

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These mutations lead to the loss of dopaminergic neurons in the substantia nigra, resulting in motor symptoms such as tremors, rigidity, and bradykinesia, as well as non-motor symptoms such as cognitive impairment and depression

69 However, the spectrum of metal-related cell failure extends beyond mere cell death to encompass loss of cell identity

Journal of Clinical Investigation, 63, 53-58

Among others, such as vitamin C, vitamin E, plant polyphenols, and carotenoids, GSH is a key non-enzymatic antioxidant (Shahidi and Zhong, 2010)