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Multidrug resistance-associated protein 2 (Mrp2) is a major apical efflux pump for biliary secretion of various amphipathic organic anion conjugates, including BAs

However, before they can be deployed, they have to be purified from cell lysates, cell culture supernatants, or biological probes

A142 reduces P-glycoprotein in the bloodbrain barrier through RAGENF-B signaling

Wang D, Pajerowska-Mukhtar K, Culler AH, Dong X

With 500mg per capsule and an easy capsule format, it is a practical option for adults who want focused support as part of a balanced and consistent lifestyle.

Rizza S, Di Leo L, Pecorari C, Giglio P, Faienza F, Montagna C, Maiani E, Puglia M, Bosisio FM, Petersen TS, et al