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Treatment of B6 mice with the GLS1 inhibitor BPTES significantly reduced histological scores in the spinal cord of affected animals, lowered the number of CD4 + T cells, IL-17A and IFN-producing CD4 + T cells in the spinal cord, substantially decreased clinical scores and weight loss, and ameliorated experimental autoimmune encephalomyelitis (47)

MIP, macrophage inflammatory protein

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Both chemotherapeutic agents (such as cisplatin and paclitaxel) and targeted therapeutic drugs (such as EGFR inhibitors and BRAF inhibitors) can induce resistant phenotypes in cancer cells after prolonged use ( 1.2 The unique significance of ferroptosis Ferroptosis was formally defined in 2012 as a form of regulated cell death that depends on iron ions and is triggered by the accumulation of lipid peroxides ( For instance, in drug-resistant lung adenocarcinoma, ferroptosis sensitivity is markedly enhanced due to upregulated ACSL4 expression and metabolic reprogramming, which synergize with immune crosstalksuch as CD8+ T cell-derived IFN-to overcome therapy resistance ( Notably, specific cancer subtypessuch as triple-negative breast cancer, lung adenocarcinoma, clear cell renal carcinoma, and mesenchymal-type tumors with high metastatic potentialexhibit heightened susceptibility to ferroptosis due to their inherent metabolic reprogramming, iron overload, and antioxidant system deficiencies