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Abnormal SR Ca 2+ leak, which is increased in this model, likely mediated by dysfunctional Ca 2+ gating of the SR channel ryanodine receptor 2 (RyR2), was reduced by treatment with MR-356 (Fig
pathology 69, 564574
In other words, even with adequate oxygen and glucose supply, neurons are unable to effectively utilize these substrates for oxidative phosphorylation
After 48 h of incubation, the CCK8 reagent (1:100, #K1018, APE-BIO, USA) was added to measure the cell viability
Philadelphia: F.A
Cytometry B Clin Cytom 84(2):6570
