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When GABA is supplemented, it binds to GABA-A receptors in the brain

doi: 10.3389/fnhum.2025.1620488 Received 30 April 2025 Accepted 13 October 2025 Published 20 November 2025 Volume 19 - 2025 Edited by David Ress, Baylor College of Medicine, United States Reviewed by Jeungchan Lee, Spaulding Rehabilitation Hospital, United States David Krolewski, University of Michigan, United States Updates Copyright 2025 Berthold, Hartmann, Farrher, Zimmermann, Jaeger, Shah, Schneider, Neuner and Rajkumar

The bloodbrain barrier in systemic inflammation
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In short, Cagrilintide offers a comprehensive approach to weight loss: it reduces appetite, improves fullness, supports blood sugar control, and shows promising synergy with existing GLP-1 therapies