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Consider Alternatives If Who Should Avoid Do not use if You are pregnant or breastfeedingeffects on fetal development are unknown You have untreated sleep apneaenhancing sleep depth could worsen breathing pauses You have severe respiratory conditions that could be affected by deeper sleep You're taking sedative medications without your doctor's knowledge You have a known allergy to any peptide compounds You have active psychosis or severe untreated mental health conditions Use with caution if !You take any medications that affect the central nervous system !You have a history of substance abusethough DSIP isn't addictive, sleep aids require responsible use !You have low blood pressureDSIP may affect cardiovascular parameters !You need to be able to wake quickly at night (parents of infants, on-call workers) !You have any autoimmune conditionsconsult your doctor first !You're elderly or have kidney/liver impairmentmay need dose adjustment Administration How do I use it

10.1056/NEJMoa1200690 [DOI] [PMC free article] [PubMed] [Google Scholar] Topalian S

Endothelial glycocalyx and cardiomyocyte damage is prevented by recombinant syndecan-1 in acute myocardial infarction

On the whole, a favorable safety profile of TRZ at low doses was demonstrated in this study, also when administered with a full dosage of gabapentin