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World Journal of Hepatology, 12(5), 184206

Estrogens reduce gastric acid secretion, alter plasma protein binding, affect P-glycoprotein activity, and modulate hepatic cytochrome P450 enzymesmost notably reducing CYP1A2 activity by up to 50%thereby increasing circulating drug levels and the risk of side effects, intolerance, or pseudo-allergic reactions (54)

doi: 10.1038/nrneurol.2017.165 3 GoetzCG

Among its findings: Protandim increased the median lifespan of male mice by 7% which the paper characterized as a small but statistically significant change that wasnt seen in female mice

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