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Although its specific pathophysiological mechanism is unknown, it is hypothesized that an abnormal degeneration of collagen fibers and loss of elastin with fibrous thickening of the endocardium represent the main cause of MV disease, also involving the left ventricle and leading to a sort of restrictive cardiomyopathy with subendocardial calcific deposits (23, 68, 69)

Redox Biol 51: 102233, 2022

Natl Cancer Inst

Orphanet J Rare Dis 13(1):219

[DOI] [PubMed] [Google Scholar] 78.Sakellariou G.K., Jackson M.J., Vasilaki A

To maintain metabolic energy equilibrium, it is necessary to eat the required type and amount of food, avoid eating empty calorie foods, and ensure correct micronutrient intake