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The study showed that the resulting 9,10-DiHOME was toxic to pulmonary alveolar epithelial cells

Building on these preclinical findings, clinical cohort studies have evaluated the impact of XO inhibitors on cardiovascular outcomes in patients with elevated cardiovascular risk

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In particular, taurine has been documented to be a direct liver X receptor (LXR-) ligand, which modulates the expression of genes implicated in reverse cholesterol transport in macrophages, this way compromising cholesterol to lipid accumulation without increasing hepatic fatty acid synthesis (224)

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