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The literature search supports the conclusion that metformin is neuroprotective against DM-induced neuronal cell degeneration in both peripheral and central nervous systems, and this effect is likely mediated via modulation of oxidative stress, inflammation, and cell death pathways.

Discontinue use if signs of irritation or rash appear

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Increased melanin levels are associated with decreased melanoma patient survival, yet the contribution of melanin to this process is unknown

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