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Schultz et al., Pyrimidine inhibitors synergize with nucleoside analogues to block SARS-CoV-2, Nature, doi:10.1038/s41586-022-04482-x

From a clinical perspective, these findings underscore the value of exploring interventions that modulate and support oxidative stress pathwaysparticularly those relative to glutathione synthesis or recyclingas adjunctive strategies for managing treatment-resistant depression

Chen et al., 2020)

The prevalence of AMD is expected to increase even further due to the rising average life expectancy with 288 million expected patients in 2040 [253,254]

167 Additionally, p53 can bypass classical death receptors by upregulating Reprimo (RPRM), which activates the HippoYAP/TAZp73 axis, leading to the expression of proapoptotic genes

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