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developed tolcapone-loaded PLGA nanosystem to reduce the hepatotoxic effect of entacapone while retaining its therapeutic efficacy in PD as illustrated in Fig

Role of Coenzymes The functional role of coenzymes is to act as transporters of chemical groups from one reactant to another

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Published pharmacokinetic studies show no direct interaction risk between these compounds, but concurrent use should align with overall treatment goals and biomarker context

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