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There are two types of COMT inhibitors available: entacapone and tolcapone

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Likewise, fecal microbiota transplantation (FMT) and rationally designed microbial consortia (e.g., the MET4 trial investigating a defined multi-strain consortium (151)) are being tested as adjuncts to immunotherapy ( Bifidobacterium CBM588 have shown clinical benefit in RCTs for patients receiving ICI therapy (149)
