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Hepatotoxic substrates and metabolism Drugs are absorbed from the sinusoidal blood into hepatocytes via transporters located in the basolateral membrane

The second and larger category comprised proteins implicated in the tricarboxylic acid (TCA) cycle (citrate hydro-lyase, aconitate hydratase, succinate dehydrogenase, isocitrate dehydrogenase and succinyl-CoA ligase), which were shown to be upregulated

Inflammation, allergies, atherogenesis, thrombogenesis, and mutagenic effects can be prevented or reduced by them (Figure 1)

Once inside the mitochondria, glutamate may deaminate back to -KG by glutamate dehydrogenase (GLUD2) and enter the TCA cycle (Fig

These bacteria not only aid in controlling infection but also support tissue regeneration by reducing inflammation and promoting cell proliferation

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