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Tirzepatide (15 mg weekly) drives 15.7% weight loss over 72 weeks in patients with obesity and T2D (45) and 22.5% weight loss in patients with obesity alone (46)

[DOI] [PubMed] [Google Scholar] 8.Rocca AS, Brubaker PL

This step-up process matters because gastrointestinal side effects such as nausea, constipation, reflux, diarrhea, or reduced appetite can be more noticeable when the dose increases too quickly

A detailed description of these effects is beyond the scope of this article, but there are a number of comprehensive review articles that cover this in detail

The default works for most peptides but not all

For low appetite: Choose concentrated options like Greek yogurt, cottage cheese, eggs, tuna, or shredded chicken