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The authors reported that these effects were associated with reduced apoptosis during the in vitro aging window and suggested that Epitalon may delay oocyte aging through modulation of mitochondrial activity and oxidative stress

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PI3K/Akt/mTOR pathways and HIF-1 are central regulators of angiogenesis, glycolysis, cancer metabolism, and cancer cell proliferation, which are essential processes for regulating the Warburg effect [127,128,129,130,131].Serine proteases (such as NE and PR3) can promote glycolytic metabolism in cancer cells by activating pathways such as HIF-1 or PI3K [132, 133]

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Recent advances, primarily based on three landmark clinical studies, namely, Nix-TB, ZeNix, and TB PRACTECAL (Nyangwa et al., 2022), led to the introduction of 69 months regimens of bedaquiline, pretomanid, linezolid, with or without moxifloxacin (BPaL-M or BPaL, respectively), offering improved outcomes compared to older treatment strategies (Johnson et al., 2024)

Tuo QZ, Bush AI, Lei P