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In response to environmental stresses such as increased temperature, the conserved transcription factor HSF-1 binds to heat shock elements (HSEs) 1 in the promoters of heat-inducible genes and induces expression of heat shock proteins (HSPs) and molecular chaperones

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Novel Nrf2-inducer prevents mitochondrial defects and oxidative stress in Friedreichs ataxia models

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However, adverse alterations in mtDNA copy number or integrity are closely associated with the development of metabolic diseases, such as diabetes (86)