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Computing the Hamiltonian during optimization requires \(O(n^2 + nm + m^2)\), with n as the number of state variables and m as the number of control variables

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designed a US-triggered MnWO X nanosystem modified with PEG (termed MnWO X -PEG) to endow the capability of GSH-enhanced ROS ( 1 O 2 and OH) production for killing malignant tumors (Figure 6D) ( X -PEG exhibited significantly time-dependent GSH consumption capacity through reducing W 6+ to W 5+ (Figure 6E), cooperating with increased ROS to achieve a powerful inhibition effect on tumors (Figure 6F)

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HSP70 and heat shock factor 1 cooperate to repress Ras-induced transcriptional activation of the c-fos gene