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Baar et al., FOXO4-DRI reduced the lifespan of primary human fibroblasts IMR90 induced into senescence by ionizing radiation by over 11 times (11.73 times), compared to the control group consisting of non-senescent IMR90 cells [127]

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Moreover, studies have indicated that the interaction between FOXOs and P53 can modulate aging in yeast and invertebrates ( Senescent cells typically exhibit enhanced resistance to apoptosis ( Accordingly, in this study, we investigated the therapeutic potential of FOXO4-DRI in vascular aging

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