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Acknowledgments The authors are grateful to the COST Action 18101 SOURDOMICS Sourdough biotechnology network towards novel, healthier and sustainable food and bioprocesses ( accessed on 29 January 2023), where the author T.E

Ong et al

Key mechanisms include the livers role in clearing peripheral -amyloid (A), the influence of hepatic enzymes and metabolites on cognitive decline, and the systemic effects of metabolic disorders on AD progression

Botanical drugs are derived from medicinal plants through standardized processes that ensure quality and contain one or more active metabolites

For instance, inhibition of the PI3K/AKT pathway in combination with BSO blocked mRNA translation and impaired tumor growth in vivo, mimicking NRF2 loss in pancreatic cancer[49]