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used mice as a model to demonstrate that the polyphenolic compounds EGC and ECG effectively alleviated A40 aggregation and protofibrillar toxicity by chelating Cu 2+ and Zn 2+ and reduced ROS production, thereby mitigating Cu 2+ -A40 and Zn 2+ -A40induced neuronal toxicity (111)

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L-NAME initially caused all vessels to disappear more rapidly and L-arginine increased the number of vessels (L-NAME R, L-arginine R, opposite ), but both induced larger pale areas (L-NAME R, L-arginine R, parallel ), all as NO-specific (NO-related) effects, as L-NAME and L-arginine regularly attenuated or antagonized each others responses (L-NAME R, L-arginine R, opposite , specific

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Thus, the prodrug Pc-(L-CA4) 2 effectively surpasses the spatial and temporal constraints of 1 O 2 in PDT, significantly enhancing its antitumor efficacy