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In human monocyte-derived dendritic cells and peripheral blood mononuclear cells (PBMCs), chloroquine inhibited poly(I:C)-induced TLR3 responses at concentrations 10 M [28]

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Expression of 2 lipid genes important in ferroptosis sensitization in renal cancers, hypoxia inducible lipid droplet associated protein (HILPDA) and perilipin 2 (PLIN2), and aberrant generation of lipid ROS were increased following FG4592 treatment (Supplemental Figure 5, A and B), and this increase was HIF-2 dependent (Supplemental Figure 5C), implicating the role of HIF-2 in driving ferroptosis through the accumulation of oxidized lipids