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In our own study we were able to show that LIF mRNA expression was up-regulated very early mainly during the first 3 weeks of cuprizone administration in both CC and cortex thereafter decreasing to normal levels in the recovery phase after toxin withdrawal (Gudi et al., 2011)

The Phase 2 clinical data makes the case numerically

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Expert Rev Gastroenterol Hepatol 13:10231031 Davies JS (2003) The cyclization of peptides and depsipeptides

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