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These manifestations, primarily driven by airway inflammation, lead to mucus production, bronchial remodeling, and bronchial hyperresponsiveness (BHR)

This foundational observation has been corroborated by numerous subsequent reports (Guan et al., 2022

Persistent NRF2 signaling, frequently mediated by the p62-KEAP1-NRF2 axis, promotes survival by activating ARE-dependent genes such as SLC7A11 , glutathione peroxidase 4 ( GPX4 ), NQO1 , HO-1 , and FTH1 , which limit lipid peroxidation, regulate iron homeostasis, and protect against ferroptosis

Correlation of MTHFR C677T Polymorphism with Male Infertility among Indian Population: Case-Control Study

These liposomes: Protect glutathione from gastric acid the lipid shell resists acid degradation far better than the glutathione molecule itself Fuse with intestinal cell membranes releasing glutathione directly inside cells rather than relying on passive absorption Enable intracellular delivery bypassing conventional absorption pathways entirely Schmitt et al